Naik NG*, Lee SC*, Veronese BHS, Ma Z, and Toth Z# (2022) Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 is not required for NSP5-mediated inhibition of type I interferon signaling pathway. Microbiology Spectrum. Accepted for publication on September 12, 2022. (Equal contribution*)
Lee SC and Toth Z# (2022) PRC1-independent binding and activity of RYBP on the KSHV genome during de novo infection PLoS Pathogens, 2022 Aug 26;18(8):e1010801
Combs LR, Spires LM, Alonso JD, Papp B, and Toth Z# (2022) KSHV RTA induces degradation of the host transcription repressor ID2 to promote the viral lytic cycle. Journal of Virology, 2022 May 23;e0010122. doi: 10.1128/jvi.00101-22.
Kumar A, Grams TR, Bloom DC, and Toth Z# (2022) Signaling pathway reporter screen with SARS-CoV-2 proteins identifies nsp5 as a repressor of p53 activity. Viruses 14(5):1039
Atyeo N, Rodriguez MD, Papp B#, and Toth Z# (2021) Clinical manifestations and epigenetic regulation of oral herpesvirus infections. Viruses 13(4), 681. (Review)
Naik NG, Lee SC, Alonso JD, and Toth Z# (2021) KDM2B overexpression facilitates lytic de novo KSHV infection by inducing AP-1 activity through interaction with the SCF E3 ubiquitin ligase complex. Journal of Virology, 2021 May 10;95(11). 95:e00331-21. https://doi.org/10.1128/JVI.00331-21
Kim YJ, Kim Y, Kumar A, Kim CW, Toth Z, Cho NH, and Lee HR (2021) Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7. PLoS Pathogens 17(1): e1009179
Naik NG, Nguyen TH, Roberts L, Fischer LT, Glickman K, Golas G, Papp B#, and Toth Z# (2020) Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV. PLoS Pathogens, 2020 Jan 10;16(1):e1008268
Golas G, Jang SJ, Naik NG, Alonso JD, Papp B, and Toth Z# (2020) Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway. Virology, 541: 160-173
Golas G, Alonso JD, and Toth Z# (2019) Characterization of de novo lytic infection of dermal lymphatic microvascular endothelial cells by Kaposi’s sarcoma-associated herpesvirus. Virology, October, 536: 27-31
Papp B#, Motlagh N, Smindak RJ, Jang SJ, Sharma A, Alonso JD, and Toth Z# (2019) Genome-wide identification of direct RTA targets reveals key host factors for KSHV lytic reactivation. Journal of Virology, 2019 Mar 1; 93(5): e01978-18.
Brice DC, Toth Z, and Diamond G (2018) LL-37 disrupts the Kaposi’s sarcoma-associated herpesvirus envelope and inhibits infection of oral epithelial cells. Antiviral Research, Aug 2, 158: 25-33
Toth Z#, Smindak R, and Papp B (2017) Inhibition of the lytic cycle of Kaposi’s sarcoma-associated herpesvirus by cohesin factors following de novo infection. Virology, Dec, 512: 25-33
Toth Z#, Papp B, Brulois KF, Choi YJ, Gao SJ and Jung JU# (2016) LANA-mediated recruitment of Polycomb Represive Complexes onto the KSHV genome during de novo infection. PLoS Pathogens, 12(9): e1005878
Brulois KF, Wong LY, Lee HR, Sivadas P, Ensser A, Feng P, Gao SJ, Toth Z# and Jung JU# (2015) The association of Kaposi’s sarcoma-associated herpesvirus ORF31 with ORF34 and ORF24 is critical for late gene expression. Journal of Virology, 89(11): 6148-54
Brulois KF, Toth Z, Wong LY, Feng P, Gao SJ, Ensser A and Jung JU (2014) KSHV K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication. Journal of Virology, 88: 9335-49
Lee HR, Doğanay S, Chung B, Toth Z, Brulois K, Lee S, Kanketayeva Z, Feng P, Ha TJ and Jung JU. (2014) Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication. Journal of Virology, 88(4): 2183-94
Toth Z#, Brulois K and Jung JU. (2014) Kaposi’s Sarcoma-Associated Herpesvirus: Biology of a Human Tumor Virus. Reference Module in Biomedical Sciences. 10.1016/B978-0-12-801238-3.00082-9. Book chapter.
Toth Z#, Brulois K and Jung JU. (2013) The chromatin landscape of Kaposi’s sarcoma-associated herpesvirus. Viruses. 5(5): 1346-73. Review.
Wong LY, Toth Z, Brulois KF, Inn KS, Lee SH, Lee HR and Jung JU (2013) Molecular Mimicry by γ-2 Herpesviruses to Modulate Host Cell Signaling Pathways. In: Brinkworth J., Pechenkina K. (eds) Primates, Pathogens, and Evolution. Developments in Primatology: Progress and Prospects. Springer, New York, NY. Book chapter.
Toth Z#, Brulois KF, Lee HR, Izumiya Y, Tepper C, Kung HJ, Jung JU# (2013) Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathogens. December 9(12): e1003813.
Wong LY, Brulois KF, Toth Z, Lee SH, Inn KS, O’Brien K, Lee HR, Cesarman E Jung JU. (2013) KSHV K4.2 immediate early gene product regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. Journal of Virology, 87(22): 12069-79
Lee SH, Toth Z, Wong LY, Brulois K, Nguyen J, Lee JY, Zandi E, Jung JU. (2012) Novel Phosphorylations of IKKγ/NEMO. MBio, 3(6):e00411-12
Toth, Z., Brulois K, Wong LY, Lee HR, Chung B, and Jung JU. (2012) NELF-mediated suppression of RNA polymerase II elongation of Kaposi’s sarcoma-associated herpesvirus lytic gene expression. Journal of Virology, (86)18: 9696-707.
Brulois KF, Chang H, Lee AS, Ensser A, Wong LY, Toth Z, Lee SH, Lee HR, Myoung J, Ganem D, Oh TK, Kim JF, Gao SJ, and Jung JU. (2012) Construction and manipulation of a new Kaposi’s sarcoma-associated herpesvirus Bacterial artificial chromosome clone. Journal of Virology, (86)18: 9708-20.
He M, Zhang W, Bakken T, Schutten M, Toth Z, Jung JU, Gill P, Cannon M, and Gao SJ. (2012) Cancer Angiogenesis Induced by Kaposi Sarcoma-Associated Herpesvirus Is Mediated by EZH2. Cancer Research, 72: 3582-92
Lee HR, Choi WC, Lee S, Hwang J, Hwang E, Guchhait K, Haas J, Toth Z, Jeon YH, Oh TK, Kim MH, Jung JU. (2011) Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. Nat. Struct. Mol. Biol, 18(12): 1336-44
Inn KS, Lee SH, Rathbun JY, Wong LY, Toth Z, Machida K, Ou JH, Jung JU. (2011) Inhibition of RIG-I mediated signaling by Kaposi’s sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. Journal of Virology, 85(20): 10899-904
Jeong JH, Bhatia A, Toth Z, Oh S, Inn KS, Liao CP, Roy-Burman P, Melamed J, Coetzee GA, Jung JU. (2011) TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth. PLoS One 6(1): e16205
Toth Z, Maglinte DT, Lee SH, Lee HR, Wong LY, Brulois KF, Lee S, Buckley JD, Laird PW, Marquez VE and Jung JU. (2010) Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathogens 6(7): e1001013
Lee H, Toth Z, Shin YC, Lee J, Chang H, Gu W, Oh TK, Kim MH and Jung JU. (2009) Kaposi’s sarcoma-associated herpesvirus viral Interferon Regulatory Factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. Journal of Virology 83(13): 6739-6747
Toth Z and Stamminger T. (2008) The human cytomegalovirus regulatory protein UL69 and its effect on mRNA export. Frontiers in Bioscience 13: 2939-2949. Review.
Lischka P, Thomas M, Toth Z, Mueller R and Stamminger T. (2007) Multimerization of human cytomegalovirus regulatory protein UL69 via a domain that is conserved within its herpesvirus homologues. Journal of General Virology 88(Pt 2): 405-410
Toth Z, Lischka P, and Stamminger T. (2006) RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA. Nucleic Acids Research 34, 1237-1249
Lischka P, Toth Z, Thomas M, Mueller R, and Stamminger T. (2006) The UL69 transactivator protein of human cytomegalovirus interacts with DExD/H-box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA. Mol. Cell. Biol. 26, 1631-1643
Raab S, Toth Z, Groot C, Stamminger T, and Hoth S. (2006) ABA-responsive RNA-binding proteins are involved in chloroplast and stromule function in Arabidopsis seedlings. Planta, 2006 Sep, 224(4):900-14
Papai G, Komony O, Toth Z, Pankotai T, Muratoglu S, and Boros I. (2005) Intimate relationship between the genes of two transcriptional coactivators, ADA2a and PIMT, of Drosophila. Gene 348, 13-23